David A. Kareken

Associate Professor, Department of Neurology, Psychology
Primary Appointment: IU School of Medicine

Current Research

Research in my laboratory uses functional neuroimaging techniques to study the human olfactory system, and its function in health and disease. We are also interested in how the chemical senses can be used to study appetitive drive, both for natural rewards and for drugs of abuse.

Select Publications

Yoder, K.K., Albrecht, D.S., Kareken, D.A., Federici, L.M., Perry, K.M., Patton, E.A., Zheng, Q-H, Mock, B.H., O’Connor, S., & Herring, C.M.  (2011). Test-retest Variability of [11C]Raclopride Binding Potential in Nontreatment-Seeking Alcoholics. Synapse, 65, 553-561.

Rupp J., Dzemidzic, M., Blekher, T., West, J., Hui, S., Wojcieszek, J., Saykin, A.J., Kareken, D.A., Foroud, T. (2011).  Vertical antisaccade latency tracks gray matter atrophy in premanifest and early manifest Huntington disease.  Neuropsychology, 25, 306-318.

Kareken, D.A., Liang, T., Wetherill, L., Dzemidzic, M., Bragulat, V., Cox, C., Talavage, T., O’Connor, S.J., & Foroud, T. (in press).  A Polymorphism in GABRA2 is Associated with the Medial Frontal Response to Alcohol Cues in an fMRI Study.  Alcoholism: Clinical and Experimental Research.

Bragulat, V., Dzemidzic, M., Bruno, C., Cox, C.A., Talavage, T.A., Considine, R.V., Kareken, D.A. (2010). Food-Related Odor Probes of Brain Reward Circuits during Hunger: A Pilot fMRI.  Obesity, 18, 1566-1571.

, D.A., Bragulat, V., Dzemidzic, M. Cox, C., Talavage, T. Davidson, D. O’Connor, S.J., & Family History of Alcoholism Mediates the Frontal Response to Alcoholic Drink Odors and Alcohol in At-Risk Drinkers (2010). NeuroImage, 50, 267-276.

Yoder, K.K., Morris, E.D., Constantinescu, C.C., Cheng, T-E., Normandin, M.D., O’Connor, S.J. and Kareken, D.A (2009). When What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration, Prediction Error, and Human Striatal Dopamine. Alcoholism: Clinical and Experimental Research, 33, 139-149.

Bragulat, V., Dzemidzic, M. Talavage, T. Davidson, D. O’Connor, S.J., & Kareken, D.A. (2008). Alcohol sensitizes cerebral responses to the odors of alcoholic drinks: An fMRI study.  Alcoholism: Clinical and Experimental Research, 32, 1124–1134.

Spina, S., Farlow, M.R.,  Unverzagt, F.W., Kareken, D.A., Murrell, J.R.,  Fraser, G., Epperson, F., Crowther, R.A. Spillantini, M.G., Goedert, M. & Ghetti, B.  (2008).   The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.  Brain. 131, 72-89.

Yoder, K.K., Kareken, D.A., Morris, E.D. (2008). “What were they thinking?” Cognitive states may influence [11C]raclopride binding potential in the striatum. Neuroscience Letters. 430 (1), 38-42.

Constantinescu, C.C., Yoder, K.K., Kareken, D.A., Bouman, C., O'Connor, S., Normandin, M., & Morris, E.D. (2008).  Estimation from PET data of transient changes in dopamine concentration induced by alcohol: Support for a non-parametric signal estimation method.  Physics in Medicine and Biology, 53, 1353–1367.

Yoder, K.K., Constantinescu, C., Kareken, D.A., Normandin, M., Cheng, T-E., O’Connor, S.J., Morris, E.D. (2007). Heterogeneous effects of alcohol on dopamine release in the striatum:  A PET study.  Alcoholism: Clinical and Experimental Research, 31, 965-73.

Plailly, J., Radnovich, A.J., Sabri, M., Royet, J-P. & Kareken, D.A. (2007).  Involvement of the left anterior insula and frontopolar gyrus in odor discrimination.  Human Brain Mapping. 28 (5): 363-372.

Yoder, KK., Kareken, DA, Seyoum, R.A., O’Connor, S.J., Wang, C.,, Zheng, Q-H., Mock, B., & Morris, E.D. (2005). Dopamine D2 receptor availability is associated with subjective responses to alcohol.  Alcoholism: Clinical and Experimental Research, 29, 965-970.

Plailly, J., Bensafi, M., Pachot-Clouard, M., Delon-Martin, C.,  Kareken, D.A., Rouby, C., Segebarth, C., & Royet, J-P. (2005). Involvement of right piriform cortex in olfactory familiarity judgments.  NeuroImage, 24, 1032-1041.

Sabri, M., Radnovich, A.J., Li, T-Q., & Kareken, D.A. (2005). Neural correlates of olfactory change detection. NeuroImage, 25, 969– 974.

Kareken, D.A., Claus, E.D., Sabri, S., Dzemidzic, M., Kosobud, A.E., Radnovich, A.J., Hector, D., Ramchandani, V.A., O’Connor, S.J., Lowe, M., & Li, T-K. (2004). Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers. Alc: Clin & Exp Res, 28, 550-557.

Kareken, D.A., Sabri, M., Radnovich, A.J., Claus, E., Foresman, B., Hector, D., &. Hutchins, G.D. (2004).  Olfactory System Activation from Sniffing: Effects in Piriform and Orbitofrontal Cortex.  NeuroImage, 22, 456-465.